Fig. 7
The α-globin domain still forms in the absence of elements critical for α-globin expression. a Gene map with DNase1 HS (green) and CTCF BS (black) genome browser tracks, followed by NG Capture-C tracks highlighting interactions from CTCF BS −39.5, Hba1/2 and CTCF BS + 44/48 viewpoints in 30 h MFL WT (red) and MFL DKO (homozygous deletions for MCS-R1/R2) (blue), with differential tracks (Δ) showing persistence of domain structure when viewed from CTCF sites even though interaction frequencies internal to the domain are affected. b Gene map with DNase1 HS (green) followed by NG Capture-C tracks highlighting interactions from MCS-R1/R2 viewpoint in MFL WT (red) and MFL AMKO (blue), with a differential track (Δ) showing persistence of domain structure in AMKO when contrasted with the absence of a domain observed in mES cells (grey)
