Fig. 2
From: Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
CBF dysfunction in ApoE4-TR mice is reversed by MnTBAP. The increase in CBF induced by whisker stimulation (a, b) or by neocortical application of acetylcholine (c), is attenuated in ApoE4-TR mice, but CBF response to neocortical application of adenosine (d) is not affected. Neocortical superfusion with the ROS scavenger MnTBAP restores neurovascular function in ApoE4-TR mice (a–c). Data are expressed as means ± SEM. N = 5/group; * p < 0.05 from WT or ApoE3, or ApoE4 + MnTBAP; one-way ANOVA and Tukey’s test
