Fig. 4

Minimal sample sizes needed for detection. The colors indicate the minimal sample sizes needed in order to detect an activation with a reasonable chance of success, i.e., in at least 50 of 100 tests (panel a). The corresponding histograms (panel b) show the number of voxels that passed the significance thresholds in at least 50 of the 100 tests for each of four different sample sizes. Note that LISA detects many more voxels at smaller sample sizes than the competing methods. For example, at sample size 40, the number of voxels detected in at least 50 of the 100 tests in the motor task were 5940 (FSL), 7292 (AFNI), 6217 (SPM), 10,401 (LISA)