Table 2 Novel GWAS loci associated with FT4

From: Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

SNP	Chr:position	Locus	A1/A2	AF1	Effect	SE	P	I ²	P _het	N	SNP function
rs4954192	2:135,632,98	ACMSD	t/c	0.43	−0.033	0.006	9.3E−09	2.6	0.424	62,680	Intron
rs6785807	3:181,718,601	SOX2-OT	a/g	0.15	−0.057	0.009	6.9E−11	7.4	0.340	55,096	Intron
rs10946313	6:19,381,386	ID4	t/c	0.63	0.044	0.006	6.2E−12	0.0	0.907	55,096	Unknown
rs9356988	6:25,777,481	SLC17A4	a/g	0.27	−0.052	0.007	5.7E−14	0.0	0.745	55,096	Intron
rs137964359*	6:26,001,742	SLC17A4	t/c	0.99	−0.200	0.032	2.1E−10	0.0	0.479	49,269	Unknown
rs17185536	6:100,620,931	LOC728012	t/c	0.24	0.071	0.008	2.7E−20	0.0	0.973	53,801	Unknown
rs67583169	8:61,212,179	CA8	c/g	0.86	0.062	0.009	7.1E−12	0.0	0.936	53,801	Unknown
rs10119187	9:4,223,660	GLIS3	t/c	0.81	0.048	0.008	8.0E−10	6.4	0.357	56,936	Intron
rs10818937	9:127,015,440	NEK6	t/c	0.32	−0.039	0.006	4.9E−11	15.8	0.196	63,971	Unknown
rs11039355	11:47,737,501	FNBP4	t/c	0.34	−0.039	0.006	7.9E−11	12.2	0.258	62,677	Near gene-5
rs4149056	12:21,331,549	SLCO1B1	t/c	0.84	−0.048	0.007	6.3E−11	0.0	0.636	67,091	Missense
rs150816132*	14:80,464,293	DIO2	a/g	0.01	−0.220	0.040	3.5E−08	24.1	0.122	38,640	Unknown
rs978055*	14:80,534,869	DIO2	a/t	0.38	0.038	0.007	1.1E−08	10.5	0.296	49,269	Unknown
rs225014	14:80,669,580	DIO2	t/c	0.64	0.047	0.006	4.6E−17	0.0	0.702	63,971	Missense
rs12323871*	14:101,852,075	DIO3OS	t/c	0.82	−0.047	0.008	1.4E−08	25.7	0.091	49,269	Unknown
rs11626434	14:101,998,443	DIO3OS	c/g	0.36	0.053	0.007	1.7E−16	40.2	0.006	55,095	Unknown
rs12907106	15:63,873,658	USP3	c/g	0.27	−0.039	0.007	3.7E−08	0.0	0.529	53,801	Intron
rs8063103	16:12,703,395	SNX29	c/g	0.85	−0.051	0.009	7.8E−09	7.9	0.335	53,801	Unknown
rs11078333	17:16,049,626	NCOR1	a/t	0.51	0.042	0.006	2.0E−12	0.0	0.513	62,677	Intron
rs56069042	18:57,914,644	MC4R	a/g	0.95	0.099	0.017	3.6E−09	0.0	0.735	58,197	Unknown

The table contains the list of the index SNPs and additional independent associations of replicated FT4 susceptibility loci. The values are provided for the combined discovery and replication sample, for additional independent hits (*) for the discovery stage only
A1 effect allele, AF1 allele frequency of A1, SE standard error of the effect, P association p-value, I² percentage of total variation across studies that is due to heterogeneity, N sample size

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Table 2 Novel GWAS loci associated with FT4

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