Fig. 2 | Nature Communications

Fig. 2

From: Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Fig. 2

Synaptic GluN2A subunit composition do not underlie inhibitory neuron-selective GNE-8324 potentiation. a Similar blockade of NMDAR EPSC by ZnCl2 in excitatory (Ext, N = 7) and inhibitory (Int, N = 7) neurons suggests similar contribution of diheteromeric GluN1/2A NMDARs to NMDAR EPSCs. b Similar GNE-8324 potentiation of NMDAR EPSCs in inhibitory neurons in the presence or absence of the GluN2B-selective inhibitor Pip18. Scale bars, 40 pA/100 ms. c d-APV inhibits NMDAR EPSCs with similar potency in inhibitory and excitatory neurons. Dose–response curve of NMDAR EPSCs to bath application of d-APV (1, 1.5, 3, 10, 50, and 100 μM) in inhibitory and excitatory neuron. N (Ext) = 7, 6, 6, 4, 5, 5; N (Int) = 5, 4, 6, 4, 5, 3. Error bars represent SEM

Back to article page