Fig. 3

Ability of drug-induced responses to reverse a SZ-related transcriptional signature. a Multi-dimensional scaling plot of individual cell lines based on connectivity scores between drugs and SZ post-mortem differentially expressed (DE) genes²³. Top 15 drugs predicted to normalize SZ post-mortem DE genes, for representative control and SZ hiPSC NPCs, as well as the neuroendocrine derived CCL, SH-SY5Y. b Top 15 drugs sorted according to predicted ability to normalize SZ post-mortem DE genes across multiple CCLs. c Summary of drugs predicted to normalize SZ post-mortem DE genes in hiPSC NPCs, based on negative connectivity with aggregated SZ and control hiPSC NPC experiments. Heatmap cells with negative connectivity score corresponding to FDR < 0.1 are indicated. Highlighted in bold are the 18 drugs (5/15 SZ-specific, 9/17 control-specific, and 4/20 non-specifically in hiPSC NPCs) that were independently identified within the top 30 drugs with SZ-specific regulation of SZ-sets in Fig. 5b