Fig. 6
From: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
Loxapine-induced regulation of FMRP targets implicates NPD-associated binding motifs. a Summary of diagnosis-dependent drug-induced perturbations in FMR1 protein (FMRP) targets from L1000 drug-screening data. Red (upregulation) and blue (downregulation) points indicate drugs that induce significant (FDR < 0.1) changes in the regulation of FMRP targets in SZ hiPSC NPCs in two FMRP target sets42,43. b SZ sets that are most differentially regulated by methylparaben and loxapine, across L1000 and RNA-seq. Squares with enrichment FDR > 0.1 are shown as white. c Known FMRP-binding motifs in DE genes of loxapine-treated SZ and control hiPSC NPCs. d FMRP targets enriched in loxapine-treated diagnosis-dependent hiPSC NPC DE genes were tested for association with SZ, ASD, and intellectual disability (ID) rare variant gene lists. e Enrichment for ACUK FMRP-binding motif variants identified in NPD mutations. f Enrichment for ACUK FMRP-binding motif variants identified in neuropsychiatric disease mutations with essential splice sites
