Fig. 2
From: Repurposing of promoters and enhancers during mammalian evolution
Repurposing of an ancestral glires enhancer. a The coordinates of a rodent P/E element, with enhancers activity in mouse and promoter activity in rat, are projected onto the rabbit genome (orange shaded area). The syntenic region in rabbit overlaps an H3K27ac peak but no H3K4me3 peak. The presence of a transcript in rat and absence of transcripts in mouse and rabbit are evident based on the RNA-seq tracks. For each species (from top to bottom) are shown: the RNA-seq coverage from liver; the assembled transcripts (only in rat); the P/E element locus; the liver H3K4me3 and H3K27Ac coverage and peaks from Villar et al. (2015). b Scheme depicting the different types of turnover events (Regulatory repurposing vs evolutionary loss) for ancestral enhancers and promoters
