Fig. 3
TDP-43 pathology distribution in the cortex and hippocampus in CamKIIa-hTDP43NLSm mice. Representative photomicrographs of p409-410 IHC staining in coronal brain sections of cortex (layers I–VI, a–h) and hippocampus (i–x) from injected CamKIIa-hTDP43NLSm mice analyzed at 1 mpi (n = 3), 3 mpi (n = 2), 5 mpi (n = 3), and 9 mpi (n = 3) in the ipsilateral (Ipsi) and contralaleral (Contra) side of injection. In the cortex, a–h show p409-410 staining in cortical layers, insets are higher magnifications of the white boxes in a–d. In the hippocampus, i–p show p409-410-positive staining in CA1 layer, stratum radiatum (rad), and stratum oriens (or). Insets are higher magnifications of the white boxes in i–l. Arrows point to p409-410-positive NCIs in CA1 layer and arrowheads point to p409-410-positive neuronal neuritic processes in rad. q–x show p409-410 staining in CA3 layer and mossy fibers (MF). Insets are a higher magnifications of the white boxes in q-t showing p409-410-positive staining in MF (q) and CA3 neurons (r–t). Scale bar = 200 µm (a–h), 100 µm (i–x), and 20 µm (insets)
