Fig. 4
Heat maps show time-dependent spreading pattern of TDP-43 pathology. Heat maps show the distribution and burden of TDP-43 pathology in neurons and in white matter tracts in the brains of CamKIIa-hTDP-43NLSm mice at different post-injection times (1, 3, 5, and 9 mpi) in ipsilateral (Ipsi) and contralateral (Contra) sides. The panels in the far left column illustrate sagittal views of the corresponding coronal planes (blue line) and three sites of the injection into cortex, hippocampus, and thalamus (red asterisks). Each panel represents a coronal plane (Bregma; 2.10 mm, 0.98 mm, −2.18 mm, −3.52 mm, −4.48 mm, and −6.84 mm) for the different post-injection times. The burden of TDP-43 pathology was graded from negative (0, gray) to most abundant (3, red) and color-coded (scale bar) in the six representative coronal sections illustrated here depicting rostral to causal brain regions. Heat maps represent the mean values of the grades TDP-43 pathology from n = 3 mice at 1 mpi, n = 2 mice at 3 mpi, n = 3 mice at 5 mpi, and n = 3 mice at 9 mpi
