Table 2 Statistical analysis of cancer cell movements in vivo

From: Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

Cell type

MSD (α)

MLE for μ

Akaike weights

  

Truncated power law

TP

P

E

B16-F0

     

 Zone 1

1.03 ± 0.04

3.58 ± 0.24

0.77

0.22

< 0.01

 Zone 2

1.38 ± 0.04

3.57 ± 0.21

0.57

0.42

< 0.01

 Zone 3

0.99 ± 0.04

3.85 ± 0.35

0.59

0.40

< 0.01

 Zone 4

–

–

–

–

–

B16-F10

     

 Zone 1

1.07 ± 0.07

4.97 ± 0.55

0.58

0.41

< 0.01

 Zone 2

1.63 ± 0.06

2.34 ± 0.21

0.90

0.09

< 0.01

 Zone 3

1.47 ± 0.05

2.66 ± 0.26

0.93

0.06

< 0.01

 Zone 4

1.87 ± 0.05

2.03 ± 0.22

0.99

< 0.01

< 0.01

  1. TP  truncated power law, P  power law, E  exponential distribution
  2. Table summarizes exponent α values and the maximum likelihood estimates, MLEs70, of the truncated power law exponents μ for cancer cell movements in vivo for the data described in Fig. 3 and 4 (± values give the 95% confidence intervals). Lower cutoff value was a = 5 min for all in vivo data sets. Away from the tumor, in zones 2–4, Akaike weights heavily favor truncated power law with 2 < μ < 3 (shown in bold) indicating Lévy walks for B16-F10. For B16F0 for all zones, distributions correspond to truncated power law with μ > 3 indicating diffusive walks. See Supplementary Movies 7 and 8. Statistics were based on the following numbers of cells and time points − B16-F0, zone #1 (n = 59 cells, m = 2,925 data points); zone #2 (n = 57, m = 2,806); zone #3 (n = 28, m = 1,383). B16-F10, zone #1 (n = 30 cells, m = 990 data points); zone #2 (n = 30, m = 990); zone #3 (n = 29, m = 957); zone #4 (n = 23, m = 759)
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