Fig. 5 | Nature Communications

Fig. 5

From: Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice

Fig. 5The alternative text for this image may have been generated using AI.

Cell autonomous reduction in axon branching of NUAK1-deficient neurons. a–f Histochemistry of the ipsilateral or contralateral side of NUAK1+/+, NUAK1F/+, and NUAK1F/F mice at P21 following in utero electroporation with CRE and the fluorescent protein mVenus. Blue: Hoescht, Red: CUX1 immunostaining. Scale bar: 250 μm. g–h Quantification of normalized mVenus fluorescence in Layer 5 of the ipsilateral cortex (g) and along a radial axis in the contralateral cortex (h). Data: Average ± SEM. NWT = 6, NHET = 13, NKO = 6. Analysis: Mann–Whitney test. ns: p > 0.05

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