Fig. 3
From: Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Transcription factor, mitochondrial and metabolic zonation along the porto-central axis. a Analysis of methylation of transcription factor binding sites across zones. The y-axis depicts the normalized average methylation difference at binding sites overlapping with DMRs for the respective transcription factor. The x-axis depicts the log10-fold enrichment of DMRs among binding sites. A detailed list and the analysis method are provided in Supplementary Data 7. b Methylation of DMRs containing a transcription factor binding site for TCF7L2: Raw methylation data for all sites are shown for the CV and PV regions. c Boxplot of the ratio of mitochondrial reads in reduced representation bisulfite sequencing data (n = 19) in pericentral (green), intermediate (red) and periportal (blue) zone. Significant differences (p < 0.001) are marked by asterisks. d Visualization of significantly enriched GO terms (p < 0.05) of zonally expressed genes. A negative GO term z-score corresponds to GO enrichment in the pericentral zone (green), a positive z-score to periportal enrichment (blue). Circle size reflects the number of zonated genes relating to the term. Exemplary GO terms are labelled, while the full list of significant GO terms can be found in Supplementary Data 5
