Fig. 1 | Nature Communications

Fig. 1

From: Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Fig. 1

Pedigrees of the families with TTNtv and a loss-of-function variant in DSC2. Square: male. Circle: female; Black filled: AF affected individual; White filled: unaffected individual; Gray filled: individual with symptoms of heart disease; Diagonal line: diseased individual. Presence of mutation is indicated with + for presence and − for absence (persons with available exomes). Patient II_6 also had thyroid disease and aortic regurgitation. Tachy.Ind.: tachycardia induced, HF: heart failure, AMI: acute myocardial infarction, DM2: diabetes type 2, HCL: hypercholesterolemia, DCM: dilated cardiomyopathy

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