Table 1 Baseline characteristics of the early-onset lone AF cohort

From: Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

 

Early-onset lone AF (n = 399)

Control group B (n = 383)

Sex, male (n (%))

334 (84%)

257 (67%)

Age, years (median (IQR))

28 (23–33)a

71 (66–76)b

Height, cm (mean (SD))

183 ( ± 8.9)

172 ( ± 8.8)

Weight, kg (mean (SD))

91.4 ( ± 49.1)

77.4 ( ± 14.7)

BMI, kg m–2 (mean (SD))

27 ( ± 15.5)

26.4 ( ± 4.9)

Smoking, current or previously (n (%))

119 (29%)

 

Alcohol consumption per week (mean (SD))

6.0 ( ± 7.2)

 

Hypertension (n (%))

0 (0%)

246 (64.4%)

Diabetes (n (%))

0 (0%)

39 (10.2%)

Heart failure (n (%))

0 (0%)

0 (0%)

Myocardial infarction (n (%))

0 (0%)

0 (0%)

Valvular heart disease (n (%))c

0 (0%)

0 (0%)

Type of AF (n (%))

  

  Paroxysmal

246 (62%)

 

  Persistent

126 (32%)

 

  Permanent

23 (6%)

 

 Family history, self-reported (n (%))

157 (39%)

 
  1. AF: atrial fibrillation, IQR: interquartile range, SD: standard deviation
  2. aAF onset age
  3. bAge at enrolment
  4. cSevere mitral regurgitation, aortic stenosis, tricuspid regurgitation, or ≥ mild mitral stenosis
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