Table 3 Clinical information on the TTNtv and DSC2 loss-of-function carriers in the AF families

Family	Pedigree ID	Sex	AF onset age	Age	Comorbidities/risk factors for AF^a	ECHO, at AF diagnosis or earliest available				ECHO, latest available
						LVDD (mm)	LA (mm)	LVEF(%)	Years from AF diagnosis	LVDD (mm)	LA (mm)	LVEF(%)	Years from AF diagnosis
E003	II-2	M	42	62		N^b	Sd^b	40–45^c	16	N^b	40	55	18
E003	II-5	F	58	71	HTN, HT	N^b	45	N^b	4	N^b	Sd^b	N^b	10
E003	III-4	M	37	47	NIDCM	67	57	15	0	70	56	30–35	8
M1023	II-4	F	63	71		N^b	N^b	35^c	0	60	32	25^c	7
M1023	III-1	M	40	50	NIDCM	67–71	51	20	3	54	44	43^c	11
M1023	III-3	F	25	52		49	38	66	22	56	44	25^c	27
M1018	III-1	M	65	69	Multi^d	Sd^b	Sd^b	N^b	0	Mild CLVH^b	D^b	60	3
M1018	IV-2	M	28	38	HTN	N^b	N^b	N^b	0	N^b	N^b	N^b	0
M1018	IV-3	M	31	40		N^b	34	N^b	0	N^b	N^b	60	7
M1039	III-2	M	23	50		N^b	N^b	N^b	16	55	N^b	60	24
M1039	III-3	M	39	51	NIDCM	Sd^b	N.A.	30^c	5	Moderat D^b	N^b	50–55	8
M1039	III-5	M	25	37		N^b	N^b	N^b	9	N^b	N^b	60	11
M1030	III-4	M	49	63	HCL	N^b	D^b	N^b	0	N^b	D^b	N^b	0
M1030	III-7	F	50	72		Mild H	Mild D^b	N^b	10	Mild H	Mild D^b	N^b	0
M1030	IV-5	M	41	46		52	43	N^b	0	52	43	N^b	0

AF: atrial fibrillation, LVDD: left ventricular diastolic diameter, LA: left atrial diameter, LVEF(%): left ventricular ejection fraction (%), D: dilated, H: hypertrophy, HT: hyperthyroidism, HTN: hypertension, HCL: hypercholesterolemia, NIDCM: nonischemic dilated cardiomyopathy, M/F: male/female, N: normal, Sd: severely dilated, CLVH: concentric left ventricular hypertrophy, TTN: titin, TTNtv: titin-truncating variants, DSC2: desmocollin 2, N.A.: not available, ECHO: echocardiography
^aDiagnosed before or within 12 months after the AF diagnosis
^bExact values not provided
^cDuring AF
^dHypertension, stroke, aortic-, and mitral prolapse and regurgitation (biological aortic valve and mitral valve repair), dilated LV

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