Table 1 Known AMR genes uncovered by machine learning

From: Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

Antibiotics

Known AMR genes

Isoniazid

katG43, inhAa20, fabG144

Rifampicin

rpoB45, rpoCa46 Rv3239c47

Ethambutol

embB48, embC17, ubiAa6, embRa17

Pyrazinamide

pncA 49

Streptomycin

rpsL50, gidB51

Ofloxacin

gyrA 52

4-Aminosalicylic acid

folCa7, thyAa53

Ethionamide

ethA54, inhAa20

Known AMR genes associated with other antibiotics

dprE155, ald5, alr56, murA57, pks258, pks1259, ppsA60, ppsD60, drrB61, drrC61, moeW55, Rv068762, mshD63, gyrB52, Rv187764, Rv019465

  1. The eight antibiotics shown each have an AUC greater than 0.80 (Supplementary Fig. 5)
  2. aNot found in top 40 ranked alleles determined by mutual information, chi-squared, and ANOVA F-test
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