Fig. 8
From: Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
Effect of FD on gap junctional integrity. a Typical examples of electron microscopic images (30,000× magnification) showing the deranged intercalated discs in MI mice, and the effects of FD overexpression by Lv-FD on the microstructure of left ventricular cardiac muscles. Marked disruption of intercalated discs and gap junction was consistently observed in infarcted myocardium (dark arrows), and such derangement was ameliorated and restored to normal conditions after pretreatment with Lv-FD, but not with Lv-FD-NC. Similar observations were repeated in another three MI mice. b Effect of FD overexpression on the protein level of connexin43 (Cx43) in MI mice. Left panel: an example of Western blot bands; right panel: averaged data on Cx43 protein level. Cx43 expression was significantly repressed by MI and rescued by Lv-FD, relative to control and Lv-FD-NC. *P < 0.05 MI or Lv-FC-NC vs. Sham; #P < 0.05 Lv-FD vs. MI; n = 6 mice for each group. (Mean ± SEM; ANOVA followed by Dunnett’s test for multiple group comparisons, Student t test for two group comparisons)
