Fig. 2 | Nature Communications

Fig. 2

From: Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

Fig. 2The alternative text for this image may have been generated using AI.

SPECT/CT images showing the whole-body spatio-temporal evolution of MSNs. PEG-TMS-coated MSNs of nominal sizes 25 nm (a, d), 50 nm (b, e), 90 nm (Supplementary Fig. 6), and 150 nm (c, f) were injected via. i.v. (a–c, Supplementary Fig. 6) or i.p. (d–f) route to understand the effect of MSN size and route of administration. PEG-PEI-coated and PEG-QA-coated MSNs, namely, QA50 (h) and PEI50 (i), were administered i.v. to explore the effect of surface chemistry. Note that (b) and (g) are identical images (shown twice for ease of comparison). Also, TMS50 (b) and QA50 (h) were compared to understand the effect of zeta potential on disposition of MSNs. Injections were followed by SPECT/CT imaging at 30 min, 5 h (6 h in case of TMS150 (i.v.)), and 24 h. All SPECT images were scaled from 0.5 to 12%ID g−1. Note: TMS90 MSN was not injected i.p.; lymph nodes and abdominal aorta were not analyzed as ROIs in the i.v. and i.p. cases, respectively

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