Fig. 1
From: Structural insights on TRPV5 gating by endogenous modulators
Lipid-bound TRPV5 structure in detergent. a A schematic representation of the TRPV5 domains per channel monomer. Dashed lines indicate regions for which a model could not be built. b Density map of lipid-bound TRPV5 at 3.9 Å resolution. Density for TRPV5 is shown in gray and the densities attributed to annular lipids are shown in khaki. c Cartoon representation of the lipid-bound TRPV5 model. The TRPV5 tetramer is depicted as pink cartoons and annular lipids as khaki sticks. d Cartoon representation of the lipid-bound TRPV5 pore highlighting the three constriction points in the selectivity filter and lower gate. e Plot of pore radii of lipid-bound TRPV5 as a function of distance through the pore. The dotted line indicates the radius of a dehydrated calcium ion
