Fig. 7 | Nature Communications

Fig. 7

From: Structural insights on TRPV5 gating by endogenous modulators

Fig. 7The alternative text for this image may have been generated using AI.

TRPV5 activation by PI(4,5)P2 and inactivation by CaM. A schematic representation of the proposed binding of both PI(4,5)P2 and CaM to TRPV5, inducing either channel activation or inactivation. A dimer of TRPV5 is shown as a gray diagram, PI(4,5)P2 is shown in orange, CaM is shown in pink and the blue circles indicate the flow of calcium ions

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