Fig. 3
From: The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism
The structure of a β2m amyloid fibril. a Oblique view of the cryo-EM map, with four layers of a de novo atomic model built into each protofilament (coloured pink and blue). The view matches the green section in Fig. 2b. b Cross-section and c side view of a single layer of the atomic model, showing the fit of model to density across the β2m subunit. d Schematic view of a single β2m subunit showing polar (purple), hydrophobic (cyan), and aromatic residues (orange) in the fibril core. The position of β-strands is indicated by a blue backbone in the schematic, together with the locations of the toe, foot, heel, and leg terminology used to describe the structure in the main text. e Distance constraints from the MAS-NMR data mapped onto the atomic model derived by cryo-EM
