Fig. 2 | Nature Communications

Fig. 2

From: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Fig. 2

The nicotinic receptor agonist DMPP lowers body weight and improves glucose tolerance in DIO mice. a Effects on body weight, b food intake, and c, d glucose tolerance following daily s.c. injections to DIO male C57Bl6j mice of vehicle (black, n = 8 for a, b; n = 7 for c, d), DMPP 1 mg/kg (light red, n = 8), DMPP 5 mg/kg (pink, n = 7 for a, b; n = 8 for c, d), and DMPP 10 mg/kg (dark red, n = 7) for 14 days. *p < 0.05, ***p < 0.001 by two-way ANOVA (a, b, c) and one-way ANOVA with Tukey post-hoc test (d). All data are presented as mean ± SEM

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