Fig. 7
The melanocortin system is indispensable for the glycemic benefits of icilin and DMPP combination therapy. a and b Effects on glucose tolerance following daily s.c. injections to DIO male C57Bl6j mice or c, d MC4R KO mice of vehicle (black, n = 8/striped white, n = 8), DMPP 5 mg/kg (red, n = 8/striped red, n = 8), icilin 5 mg/kg (blue, n = 8/striped blue, n = 8), or the combination of DMPP 5 mg/kg and icilin 5 mg/kg (purple, n = 8/striped purple, n = 7) for 7 days. e and f Effects on glucose tolerance following daily s.c. injections to DIO male C57Bl6j mice or g, h UCP1 KO mice of vehicle (black, n = 7/gray, n = 7) or the combination of DMPP 5 mg/kg and icilin 5 mg/kg (purple, n = 7/light blue, n = 7) for 7 days. *p < 0.05, **p < 0.01, ***p < 0.001 by two-way ANOVA (a, c, e, g), one-way ANOVA wit Tukey post-hoc test (b, d), or two-tailed Student’s t-test (f, h). All data are presented as mean ± SEM
