Fig. 2
From: APOE ε2 is associated with increased tau pathology in primary tauopathy
Behavioral abnormalities and compromised synaptic integrity in TauP301L-apoE2 mice. Behavioral performance was assessed in control mice (Ctrl, AAV-GFP-injected, n = 12 mice per group, mixed gender) and TauP301L-apoE2, -apoE3, and -apoE4 mice (n = 13 mice for TauP301L-apoE2 group, n = 20 mice for TauP301L-apoE3 group, n = 22 mice for TauP301L-apoE4 group, mixed gender) at 6 months of age. a Open-field analysis was assessed and the ratios of time spent in the center quadrant to total distance traveled in the open-field apparatus are shown. b Exploratory behavior was evaluated in the elevated plus maze and the ratios of the time spent in open arms to close arms are shown. c, d Fear conditioning test was utilized to examine the associative memory. The percentage of the time with freezing behavior in response to stimulus during context (c) and cued (d) tests is shown. Data represent mean ± SEM. e–g The amount of GluR2 and PSD95 in the cortical RIPA lysate was examined by western blotting for control mice and TauP301L-apoE mice (n = 6 mice per group, mixed gender) at 6 months of age. Results were normalized to β-actin levels. Data are expressed as mean ± SEM. Mann-Whitney tests followed by Bonferroni correction for multiple comparisons were used. *P < 0.0167; N.S. not significant
