Table 1 Associations of APOE genotype with tau lesions of PSP

	Association with CBs		Association with NFTs		Association with TAs		Association with NTs
APOE genotype (comparisons made vs. the ε3/ε3 reference genotype)	Regression coefficient (95% CI)	P-value	Regression coefficient (95% CI)	P-value	Regression coefficient (95% CI)	P-value	Regression coefficient (95% CI)	P-value
Presence of ε2	0.07 (0.00, 0.13)	0.045	0.06 (0.00, 0.12)	0.059	0.10 (0.03, 0.17)	0.004	0.08 (0.01, 0.16)	0.029
Presence of ε4	0.00 (−0.06, 0.07)	0.88	0.00 (−0.06, 0.06)	0.99	0.04 (−0.03, 0.10)	0.23	0.01 (−0.06, 0.08)	0.77
Presence of ε2/ε2	−0.03 (−0.23, 0.16)	0.74	0.10 (−0.08, 0.28)	0.25	−0.07 (−0.28, 0.13)	0.48	0.01 (−0.21, 0.23)	0.92
Presence of ε2/ε3	0.11 (0.03, 0.18)	0.004	0.05 (−0.02, 0.12)	0.15	0.12 (0.05, 0.20)	0.002	0.11 (0.03, 0.19)	0.010
Presence of ε2/ε4	−0.07 (−0.23, 0.09)	0.40	0.06 (−0.09, 0.21)	0.41	0.11 (−0.06, 0.28)	0.19	−0.01 (−0.19, 0.17)	0.92
Presence of ε3/ε4	0.02 (−0.05, 0.08)	0.62	0.01 (−0.05, 0.07)	0.86	0.04 (−0.03, 0.11)	0.23	0.03 (−0.05, 0.10)	0.47
Presence of ε4/ε4	0.03 (−0.17, 0.24)	0.77	−0.14 (−0.33, 0.05)	0.15	−0.07 (−0.28, 0.14)	0.51	−0.11 (−0.34, 0.12)	0.35

Regression coefficients, 95% CIs, and P-values result from linear regression models adjusted for age at death, gender, Braak NFT stage, and Thal amyloid phase. Regression coefficients are interpreted as difference in the mean score of the given neuropathological feature (where scores were calculated by averaging the 0–3 measures across all anatomical structures) between the given APOE genotype and the ε3/ε3 reference genotype. P-values ≤ 0.0125 were considered as statistically significant after applying a Bonferroni correction for the four statistical tests that were performed for each different APOE genotype categorization
CB coiled body, NFT neurofibrillary tangle, TA tufted astrocyte, NT neuropil thread, CI confidence interval

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