Table 2 Select putative gene-level associations from prioritization analyses

From: Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

Phenotype

Pathway (# of genes, log10BF)

Gene

Baseline P1

Enrichment P1

Adult height

Endochondral ossification (65, 68.9)

HDAC4

0.98

1.00

PTH1R

0.94

1.00

FGFR1

0.67

0.97

MMP13

0.45

0.93

Inflammatory bowel disease

Cytokine receptor interactiona (253, 21.3)

TNFRSF14

0.98

1.00

FAS

0.82

0.99

IL6

0.27

0.87

Rheumatoid arthritis

NFAT-dependent transcriptionb (45, 10.0)

PTGS2

0.74

0.98

PPARG

0.28

0.98

Coronary artery disease

p75(NTR)-mediated signaling (55, 16.0)

FURIN

0.69

0.99

MMP3

0.43

0.97

High-density lipoprotein

Lipid digestion and transportc (58, 89.8)

CUBN

0.24

1.00

ABCG1

0.01

0.89

  1. BF: enrichment Bayes factor; P1: posterior probability that at least one SNP within 100 kb of the transcribed region of a given gene has nonzero effect on the target trait. NFAT: nuclear factor of activated T cells; p75(NTR): p75 neurotrophin receptor
  2. a The full name of this pathway is “cytokine-cytokine receptor interaction”
  3. b The full name of this pathway is “calcineurin-regulated NFAT-dependent transcription in lymphocytes”
  4. c The full name of this pathway is “lipid digestion, mobilization, and transport”
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