Fig. 3
From: A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
Observations underestimate the number of distinct HIV sequences during ART. Observed sequence richness underestimates the true HIV sequence richness. For both data sources, Chao1 provides an estimate of the lower bound (min) of true sequence richness (error bars are asymmetric confidence intervals, see Supplementary Methods). In all cases, Chao1 estimates are above observed values. Our conservative modeling technique estimates a much higher upper bound (max) for true sequence richness. Nevertheless, the total HIV sequence population size (dashed lines: 109 for total HIV DNA and 107 for replication-competent HIV) is 1–2 orders of magnitude above the upper bound estimates for sequence richness, suggesting substantial clonality of HIV sequences. All marker colors correspond to data in Fig. 2a and b
