Fig. 7
From: A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
Most infected cells are generated via proliferation within 6 months of ART initiation. Model simulations contrast the number of cells generated by viral replication with those generated by cellular proliferation. The fraction of cells that arose due to viral replication at a time point is referred to as the current replication percentage. The fraction of cells remaining that arose at any time due to viral replication is referred to as the net replication percentage. Simulations are identical except for different assumptions regarding a drug sanctuary (IS) in each column. a Moving left to right, we assume a static drug sanctuary, a slowly declining drug sanctuary and no drug sanctuary. b Under all assumptions, once ART is initiated, most current infected cells arise due to cellular proliferation as opposed to HIV replication after 12 months of ART. c Current latently infected reservoir cells (I3) are generated almost entirely by proliferation soon after ART is initiated under all conditions. d The fraction of cells that remain that were generated by replication at any time (net) overestimates the fraction generated current percentage during the first 6 months of ART—a trend that is more notable when the reservoir contains a higher proportion of slowly proliferating naive T cells. Importantly, this is the quantity that would be observed experimentally (see Fig. 8). e Pie charts indicate reservoir compositions of T cell subsets from published data and correspond with colored lines in a–d
