Fig. 3
Hyperpolarization disinhibits Kv1.2 co-expressed with Slc7a5. a ltk-mouse fibroblast cells transfected with Kv1.2 + Slc7a5 (1:1) were held at a range of voltages: −80 mV (n = 7), −100 mV (n = 12) and −120 mV (n = 25). Currents were measured at +10 mV (50 ms pulses, every 300 ms), and normalized to the peak current after 30 s at −120 mV (mean ± s.d.). b Cell-by-cell current density (at +10 mV) of the first (gray) and final (green) pulses of a train of depolarizations with a −120 mV holding voltage. c Fold change between the initial and final test pulses of a 30 s pulse train with the indicated holding voltages (mean ± s.d.: 1.4 ± 0.1 at −80 mV; 1.6 ± 0.3 at −100 mV; 5 ± 2-fold at −120 mV, ANOVA followed by Dunnett’s post hoc test was used to compare groups)
