Fig. 3
From: Sources, propagation and consequences of stochasticity in cellular growth
Growth limitations determine the sources of growth fluctuations. a Fluctuations in transcription of transporter mRNAs and their stochastic partitioning dominate growth variability when nutrient uptake is growth-limiting (import rate < enzymatic rate, see Supplementary Table 1). Other processes such as translation of proteins are largely negligible. b When catabolism limits growth (import rate > enzymatic rate), fluctuations in enzymatic mRNAs instead explain most of the observed variation. We vary catabolic turnover rates vm relative to nutrient uptake rate vt. c In a reduced model with constant supply of resources, ribosome production limits growth. Growth variability results from transcription, translation and partitioning of lowly abundant r- and q-mRNAs
