Fig. 2

GWAS variants intersecting with regulatory regions defined on the basis of acetylation of histone H3 at lysine residue K27 (H3K27ac). Shown are results for two of the loci reported to associate with BPH/LUTS from an analysis of non-coding risk variants intersecting with regulatory regions defined on the basis of acetylation of histone H3 at lysine residue K27 (H3K27ac), indicative of regulatory regions, in primary prostate epithelial cells. The y-axis shows the ChIP-seq signal for the H3K27ac mark represented as negative log₁₀ of the P-value and the x-axis shows the genomic location (hg38). The black tick marks (top of panels a and b) indicate the position of variants found in strong LD (r² > 0.8) with the lead variant, defining an LD class, wherein rs numbers are shown for those residing within H3K27ac significant regions. a At 12q24.21 four variants reside within an H3K27ac marked region (rs71807, rs8853, rs484443, and rs551510). b At 13q14.3, only one variant, rs2274069, belonging to the LD class of the lead variant resides within a H3K27ac marked region. This is the promoter region for RNASEH2B, located within 500 bp from the transcription start site of the gene