Fig. 2
From: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Karyotyping of the murine tumors and comparison of the global genetic landscapes with human tumors. a Complex genome rearrangements are associated with increased chromosome numbers and with structural aberrations. Left panel, M-FISH analysis of medulloblastoma cells from a XRCC4/p53-deficient mouse. b Quantification of the structural and numerical aberrations detected by M-FISH analyses for medulloblastoma cells derived from four Xrcc4/p53-deficient mice. c Indel, structural variant and SNV burdens by whole-genome sequencing in human high-grade gliomas (HGGs, n = 32) and medulloblastomas (SHH MBs, n = 68) as compared to murine HGGs and MBs (n = 14, colored according to the genotypes). Human SHH MBs with TP53 mutations all show complex genome rearrangements (dark purple) *p < 0.05, **p < 0.01, beta-regression analysis
