Fig. 7
From: Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
Model of directed migration of mammary cells in oxygen gradients. Mitochondrial respiration generates hypoxia and an oxygen gradient that in turn generates a ROS gradient since oxygen is required for ROS production. At the cell level, these ROS, that are likely more abundant at the front edge than at the lagging edge induce a differential activation of EGF receptors that sustains directionality
