Fig. 1
From: Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation
YAP expression is decreased in postnatal cartilage growth and osteoarthritic cartilages. a Safranin O staining (Top) and immunohistochemistry analysis of YAP expression (Bottom) in wild-type mice with age as indicated. Scale bars, 100 μm. b Statistical analysis of the percentage of YAP+ chondrocytes (brown) in articular cartilage from (a) (n = 6 per group). c Safranin O staining (Top) and immunohistochemistry analysis of YAP expression (Bottom) of 10-week-old wild-type mice after 4 or 10 weeks anterior cruciate ligament transection (ACLT) surgery respectively. Scale bars, 100 μm. d Statistical analysis of the percentage of YAP+ chondrocytes (brown) in articular cartilage from (c) (n = 6 per group). e Safranin O staining (Top) and immunohistochemistry analysis of YAP expression (Bottom) in articular cartilage of human patients with different grade of OA. Scale bars, 100 μm. f Statistical analysis of the percentage of YAP chondrocytes (brown) in articular cartilages from e. Numbers of samples examined are indicated at the bottom of the graphs. All data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, with One-way ANOVA followed by Tukey’s test
