Fig. 1

Dynamic NuRD binding sites map to active promoters and enhancers in ESCs. a Venn diagrams summarizing NuRD ChIP-seq results in embryonic stem cells (ESC) and neural progenitor cells (NPC). b UCSC genome browser screenshots of example loci where NuRD binding is shared between ESC and NPC (left), enriched in ESC (middle), or enriched in NPC (right). c Heat map showing the ChIP-seq read density for MBD3 and CHD4 in ESC and NPC, centred on the union of MBD3 peaks from ESC and NPC. d Genomic distribution of NuRD ChIP-seq peaks from each class as shown in b and c. TSS peaks were +5 kb/−1 kb from a transcription start site. e Band plots of four different histone marks and p300 (in ESCs, publicly available data¹⁹) ChIP-seq at MBD3 binding sites for each class of NuRD binding. See also Supplementary Fig. 1