Fig. 3

Regional association plots for burdens in APOC3, FAM189B, UGT1A9, ADIPOQ, and GGT1. Red lines denote the burden P-value and extend over the tested gene. Purple lines indicate the conditioned P-value for the variant described in the text (variants rs887829, rs62625753, and rs3859862 in c, d, e. respectively). Small grey dots indicate single-point P-value for variants in the region not included in the test. Larger coloured dots represent variants included in the test, with size and colour proportional to the score used in the most significant test (Supplementary Table 1 and Supplementary Data File 1). When no weights are applied (a and b), included variants are coloured blue-green. In the gene track below the regional plots, green bars below the gene, if present, denote regulatory regions associated with the gene which were used to include variants in the burden. These are present only for genes where regulatory regions were included in the burden