Fig. 5
From: Gene inversion potentiates bacterial evolvability and virulence
New head-on alleles are retained after inversion. a The distribution of GC skew values for all co-directional (leading strand, gray) or head-on (lagging strand, black) genes are plotted, one column per gene. Columns are sorted from the highest to lowest GC value resulting in the appearance of a curve. Values below zero represent inverted genes, whereas values above zero suggest long-term orientation conservation. Dashed lines highlight the inflection point between positive and negative value in each group. b The magnitude of the average GC skew of inverted head-on genes (those with a negative GC skew, black) is diminished relative to retained co-directional genes (those with a positive GC skew, gray). Error bars represent the standard error of the mean. Statistical significance of the difference in magnitude between the two groups (CD+ vs. HO−) was determined per species using Z-test. **p < 0.0001
