Table 3 Univariate analysis of biomarkers before treatment

From: Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Parameter

p-value

Total tumor volumea

0.0001

WVTb

0.004

EVTb

0.004

EF

0.004

LDH

0.005

ECOG performance status

0.006

VEGFA

0.008

IAUC

0.012

K trans

0.017

Cytokeratin18

0.13

VEGFR2

0.19

  1. Clinical, circulating and imaging biomarkers were analyzed using univariate Cox proportional hazard regression analysis to examine their prognostic significance with respect to progression-free survival. Biomarkers with univariate p-values that were less than 0.05 (listed in this table) were included in the subsequent multi-variate analysis (Table 4)
  2. aTotal tumor volume calculated from CT scan
  3. bWTV and ETV calculated from MRI scan
  4. EF ejection fraction, ETV enhancing tumor volume, WTV whole tumor volume, LDH lactose dehydrogenase, ECOG Eastern Cooperative Group, VEGFA and R2 vascular endothelial growth factor A and receptor 2, IAUC initial area under the contrast agent concentration curve; Ktrans endothelial transfer constant, MRI magnetic resonance imaging
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