Fig. 3
From: Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
Perforin-1 is critical for T cell-mediated acute liver failure. a Serum levels of IFN-γ, TNF, and IL-6 on day 3 after transfer of CD44-OT-I cells and infection with 1 × 109 PFU AdGOL or 1 × 109 PFU AdGL. b, d, f, h ALT activity in the serum and c, e, g, i percentage of loss of body weight in ifnγr−/− mice (b, c), wt mice with or without antibiotics treatment starting at day −7 (d, e), wt mice that were treated anti-FasL, anti-TNF, or control antibody on day 2 post infection (f, g) or wt mice that received wt or Prf1−/− OT-I T cells (h, i). j Survival curves of wt mice that received wt or Prf1−/− OT-I T cells. Data are representative of two (b–g) or three independent experiments (n ≥ 3 (d–i) or n ≥ 4 (a–c, j)). Error bars indicate the mean ± SD. Comparison between groups was calculated using unpaired Student’s t test (a–i) or log-rank test (j). ABX antibiotics **p < 0.01; ***p < 0.001
