Fig. 1
From: Non-canonical nucleosides and chemistry of the emergence of life

LUCA’s modified bases. a The chemical structure of ribonucleic acid (RNA) and of some modified bases. Different (thio)methylation sites and amino acid purine modifications in LUCA are marked in red. b Amidine salts are converted into nitrosopyrimidines, which then form formamidopyrimidines. Reaction with ribose provides a set of canonical and non-canonical nucleosides that are assumed to have been present in LUCA