Fig. 2

Responses to phytochemical toxins and insecticides (SCD-d6AE relative to SCD). The SCD-d6AE strain was derived from SCD by knocking out the CYP6AE cluster. Increased folds in susceptibility were calculated as LC50 of SCD/LC50 of SCD-d6AE. LC50 values were considered significantly different if their fiducial limits did not overlap, and asterisks indicate statistical significance of LC50s between the two strains. Phytochemical toxins: xanthotoxin, gossypol acetate, 2-tridecanone, nicotine, and coumarin. Insecticides: esfenvalerate, indoxacarb, emamectin benzoate, and chlorantraniliprole