Fig. 1
From: Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
Flowchart of data mining, extraction and fingerprint generation procedures. Keyword-based search of online databases and manual grey search of literature identified 214,288 publications since 1984, out of which 15,777 were screened for content. Three categories of data were extracted from 3838 studies that fulfilled the inclusion criteria (microdialysis AND rat AND brain AND systemic drug administration). For each drug, dose pairing, the normalized effect was calculated as a meta-analysis weighted by the number of animals used in each study and the robustness of the values were estimated by sensitivity analysis with respect to covariates such as age, strain, sex and microdialysis parameters. The data was then transformed into bit arrays which represent the neurochemical response fingerprints within the neurochemical connectome of the rat brain
