Fig. 5
From: Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
Systematic analysis of bioactivities against protein targets associated with neurochemical changes. A larger percentage (red) indicates which protein targets are more often predicted to be targeted by drugs which change a given neurotransmitter level. Target families are shown to frequently cluster together, due to their similarity in bioactivity profiles (i.e. compounds which elicit neurochemical response more frequently interact at a complement of targets within protein families), as illustrated by the voltage-gated sodium channel Alpha subunit 1 and type III subunit (SCN1A and SCN3A) and the cholinergic muscarinic receptors 4 and 5 (CHRM4 and CHRM5) also corroborated in literature56,57. N.B.: Only drug targets that are clustering to at least three neurochemicals are listed here
