Fig. 7 | Nature Communications

Fig. 7

From: Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

Fig. 7

Hypothesis schematic. Youthful levels of the circulating hormone α-Klotho are critical for the maintenance of muscle stem cell (MuSC) mitochondrial ultrastructure, thereby limiting mtDNA damage and mitochondrial ROS production. This maintenance of healthy mitochondria within MuSCs is required for MuSC activation and contribution to functional skeletal muscle regeneration. However, age-related declines in α-Klotho causes disrupted mitochondrial ultrastructure, increased mtDNA damage, and ROS accumulation, resulting in cellular senescence and impaired skeletal muscle regeneration

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