Fig. 4
From: Integrative epigenetic taxonomy of primary prostate cancer
Integrative clustering of prostate cancer samples. a Heatmap displays the consensus matrix of integrative analysis (MIV-NMF) on the basis of RNA-seq, AR, H3K27ac, H3K4me3, and H3K27me3 ChIP-seq for k = 3 (three clusters). Rows and columns are samples, and the more frequently samples occur in the same cluster, the darker the color blue. b Bar plot showing the Pearson’s correlation coefficient capturing the contribution of each data type in integrative clustering. Error bars indicate the standard deviation. c The sample classification into three clusters according to integrative clustering analysis is shown in the top row. The bottom panels show the resultant clustering according to consensus clustering analysis based on each individual data type sorted by integrative cluster assignment. Chi-square tests were used to test for association between the integrative clusters and clusters obtained in each individual data type
