Fig. 6
Monocyte-derived macrophages adopt a conserved gene signature associated with neuroinflammation and neurodegeneration. a–d Expression (z-scores) of the F4/80low and F4/80hi gene signatures from Fig. 5d in published datasets. These studies were chosen because they compared the transcriptomic profiles of CNS-infiltrating macrophages with resident microglia, with or without microglial depletion. Normalized RNA-seq expression counts were used to plot the data. WBI whole body irradiation. ICT intracerebral transplantation. e Gene set enrichment analysis visualized using BubbleGum. Color indicates the cell subset showing enrichment, and the size and color of circles represent enrichment score and significance, respectively. Numbers in parentheses denote the number of genes in the gene set. BMDM bone-marrow derived macrophage MgND neurodegeneration-associated microglia
