Fig. 6
From: The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
Identification of direct Ash1L targets. a Gene set enrichment analysis enrichment plot for Ash1L ChIP-seq peak-associated genes (n = 146, 96 expressed in myoblasts) obtained from the gene list pre-ranked according to the log 2 FC in myoblast KD vs. NS RNA-seq experiment. The leading edge analysis identified 45 genes as significantly downregulated and correlated to Ash1L binding. b Bipartite graph showing significantly enriched categories (KEGG, Biocarta, WikiPathways, Reactome, GO BP/MF/CC) (FDR <0.05, Z-score <−1.75, and n ≥ 3) and their associated genes within the 45 direct targets identified with the GSEA analysis in a. The size of the gene nodes is proportional to the log 2 FC of downregulation, while the size of the category nodes is proportional to the significance of enrichment (−log 10 Adj. p value)
