Table 4 Genetic correlation between CHD and stroke traits with cIMT and plaque, and cIMT with plaque using LD score and meta-GWAS

CHD^a

cIMT

0.20

0.05

4.1114

4 × 10⁻⁵

Any stroke

cIMT

0.30

0.07

4.2301

2.3 × 10⁻⁵

Ischemic stroke^b

cIMT

0.31

0.07

4.646

3.4 × 10⁻⁶

Cardio-embolic stroke^b

cIMT

0.10

0.09

1.0729

0.28

Small vessel disease stroke^b

cIMT

0.33

0.18

1.8728

0.06

CHD^a

Carotid plaque

0.52

0.08

6.4263

1.3 × 10⁻¹⁰

Any stroke^b

Carotid plaque

0.28

0.10

2.7097

0.007

Ischemic stroke^b

Carotid plaque

0.27

0.10

2.6578

0.008

Cardio-embolic stroke^b

Carotid plaque

0.06

0.14

0.4684

0.64

Small vessel disease stroke^b

Carotid plaque

−0.03

0.24

−0.1344

0.89

Plaque

cIMT

0.40

0.10

3.9667

7.3 × 10⁻⁵