Fig. 7

Fine-tuned regulation of SOCS1 induction by inflammasome and type I IFN signaling dictates host resistance to YM infection. a–c WT and deficient (Aim2^−/−, Nlrp3^−/−, Casp1^−/−, Il1r1^−/−, and Mavs^−/−) mice (n = 5) were infected with YM, RNA from pDCs was isolated at 18 h post infection and used for expression analysis of Socs1 (a), Ifna and Ifnb (b) by using qPCR, and serum levels of IFN-α and IFN-β in WT and deficient mice at 24 h after P. yoelii YM infection are shown in c. d–f WT and deficient (Aim2^−/−, Nlrp3^−/−, Casp1^−/−, Il1r1^−/−, and Mavs^−/−) mice (n = 5) were infected with high dose (1 × 10⁶ iRBCs, d), medium dose (0.75 × 10⁶ iRBCs, e) or low dose (0.5 × 10⁶ iRBCs, f) of P. yoelii YM. Daily parasitemias and mortality rates of WT and deficient mice after P. yoelii YM infection are shown. Data are plotted as mean ± SD and representative of three independent experiments with similar results. *p < 0.05, **p < 0.01, ***p < 0.001 vs. corresponding control. NS, not significant. Dagger denotes mouse death